2025年 業績

＜論文＞

1. 1. Profiling in advanced hepatocellular carcinoma: opening new doors for precision medicine.
      Hirotsu Y, Mochizuki H, Omata M.
      Hepatol Int. 2025;19(1):87-89.
   2. Germline Pathogenic Variants and Clinical Outcomes in Asian Patients With Breast Cancer.
      Kitadai R, Yazaki S, Kuchiba A, Yamanaka T, Shiino S, Yamauchi C, Harano K, Saito M, Hirotsu Y, Aiba H, Yoshida T, Hamamoto R, Shimizu C, Shimomura A, Kojima Y, Shimoi T, Momozawa Y, Sudo K, Yoshida M, Sunami K, Hori M, Katanoda K, Shimada Y, Yamashita Y, Kogawa T, Murata T, Fujiwara S, Miyagi Y, Nakagomi H, Tachibana K, Omata M, Ohtake T, Suto A, Onishi T, Naito Y, Yamashita T, Yonemori K, Kohno T, Shiraishi K.
      Cancer Sci. 2025;116(4):1048-1058. 
   3. Decoding Genomic Diversity to Guide Tumor Lesion-Specific Treatment of Multifocal Hepatocellular Carcinoma.
      Amemiya K, Hirotsu Y, Iimuro Y, Tajiri R, Oyama T, Obi S, Mochizuki H, Omata M.
      Cancer Med. 2025;14(7):e70814. 
   4. Hepatic immune-related adverse event increased the overall survival of patients with malignancies treated with immune checkpoint inhibitors.
      Matsumoto K, Kanda T, Wakatsuki J, Kim YJ, Yokouchi R, Sato N, Hasegawa Y, Amemiya K, Hirotsu Y, Hirose S, Imai Y, Takaoka S, Amano H, Asakawa Y, Nagasaka K, Asahina Y, Kojima Y, Toyama S, Mochizuki H, Obi S, Omata M.
      Hepatol Int. 2025;19(5):1221-1230. 
   5. Impact of germline variants on breast and ovarian cancer risk in Japanese women: an original cohort study and meta-analysis.
      Yazaki S, Hori M, Aiba H, Momozawa Y, Yoshida M, Shiino S, Harano K, Yamauchi C, Yamanaka T, Miwa M, Matsuda K, Kawai Y, Kobayashi-Kato M, Kitagawa M, Saito M, Nakagomi H, Tachibana K, Sakamoto I, Takahashi K, Asami Y, Katanoda K, Kuchiba A, Yoshida H, Ishikawa M, Shimoi T, Sudo K, Shimizu C, Shimomura A, Murata T, Yamashita Y, Kogawa T, Fujiwara S, Saji H, Kato H, Miyagi E, Iwasaki Y, Aoi T, Takata S, Ogasawara A, Ohtake T, Fujimori K, Hirotsu Y, Nagashima M, Komatsu M, Hamamoto R, Hirata M, Yoshida T, Honda T, Hiranuma K, Matsuda M, Shimada Y, Sunami K, Noiri E, Omae Y, Matsumoto K, Okamoto A, Omata M, Watanabe T, Miyagi Y, Murakami Y, Tokunaga K, Hasegawa K, Kato T, Onishi T, Yamashita T, Naito Y, Suto A, Yonemori K, Kohno T, Shiraisihi K; BioBank Japan Project; NCBN Controls WGS Consortium.
      EBioMedicine. 2025;116:105758.
   6. Genetic Variation in Background Mucosa Across Different Grades of Chronic Esophagitis.
      Ohashi T, Okimoto K, Kaneko T, Akizue N, Hirotsu Y, Amemiya K, Krosugi A, Ishikawa T, Ohta Y, Taida T, Matsumura T, Nishimura M, Matsushita K, Mochizuki H, Matusaka K, Ikeda JI, Kato J, Omata M.
      J Gastroenterol Hepatol. 2025. (in press)
   7. Preoperative molecular classification of endometrial cancer: Validation through biopsy and matched hysterectomy specimens.
      Nozaki T, Sakamoto I, Kagami K, Matsuda K, Uchida M, Kouchi Y, Amemiya K, Hirotsu Y, Tajiri R, Oyama T, Omata M.
      Gynecol Oncol. 2025;203:105-111.
   8. Impact of infection timing before vaccination on the effectiveness of COVID-19 mRNA vaccine in healthcare workers.
      Takatori M, Nemoto A, Hirotsu Y, Mikawa T, Honda R, Ono M, Endo A, Shibamori K, Shiozawa R, Maejima M, Shibusawa M, Natori Y, Nagakubo Y, Hosaka K, Hoshiai M, Miyashita Y, Wakasugi M, Mochizuki H, Omata M.
      Microbiol Spectr. 2025;13(12):e0128825.
   9. Analysis of perioperative chemotherapy-mediated genomic changes in gastric cancer.
      Ikegame K, Omori H, Hada M, Watanabe H, Takano A, Kimura A, Inoue M, Furuya K, Yasutome M, Iimuro Y, Nakagomi H, Amemiya K, Hirotsu Y, Mochizuki H, Omata M.
      BMC Gastroenterol. 2025;25(1):832.
   10. Germline variants of the POLH and RAD51 genes are candidate variants associated with risk of hormone receptor-negative young-onset breast cancer.
       Yazaki S, Kitadai R, Momozawa Y, Yoshida T, Yamanaka T, Shiino S, Yamauchi C, Harano K, Saito M, Hirotsu Y, Aiba H, Hamamoto R, Shimizu C, Shimomura A, Shimoi T, Sudo K, Yoshida M, Sunami K, Shiraishi Y, Kuchiba A, Hori M, Katanoda K, Takata S, Ogawa A, Torasawa M, Mochizuki A, Shimada Y, Hiranuma K, Fujii E, Hirata M, Yamashita Y, Kogawa T, Murata T, Fujiwara S, Miyagi Y, Nakagomi H, Tachibana K, Matsuda K, Murakami Y, Tokunaga K, Kawai Y; NCBN Controls WGS Consortium; Project BJ, Omata M, Ohtake T, Suto A, Onishi T, Naito Y, Yamashita T, Yonemori K, Kohno T, Shiraishi K.
       NPJ Breast Cancer. 2025;11(1):133.
   11. Prediction of Postoperative Intravesical Recurrence Using Urine DNA Monitoring in Nonmuscular-Invasive Urothelial Bladder Cancer.
       Shiozaki M, Minagawa T, Yokoyama H, Hirotsu Y, Oyama T, Omata M, Akiyama Y.
       Int J Urol. 2025 in press